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p2ry12 ko mice  (Jackson Laboratory)

 
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    Structured Review

    Jackson Laboratory p2ry12 ko mice
    a, Time course of modified Racine seizure scores in <t>P2RY12-deficient</t> mice. b , Quantification of peak seizure score in P2RY12 ⁻/⁻ mice (p < 0.05, unpaired t-test). c, Kaplan–Meier survival analysis of survival probability in P2RY12 ⁻/⁻ mice (p < 0.05, log-rank test). N = 11-18 mice each. d , Representative confocal images of IBA1 (green) and P2RY12 (magenta) immunostaining in cWT(P2RY12 fl/fl :CX3CR1 Cre/+ ) and conditional knockout cKO (P2RY12 fl/fl :CX3CR1 Cre/+) mice confirm selective microglial deletion of P2RY12. e , Quantification of P2RY12 mean fluorescence intensity in cWT and cKO mice (unpaired t-test). N = 3 mice each. f , Tail bleeding assay comparing platelet function across genotypes confirming microglia-specific targeting (p < 0.0001, one-way ANOVA with Tukey’s post hoc test). N = 4-8 mice each. g-i , Modified Racine seizure scores overtime of cWT and cKO ( g ), peak seizure score ( h , p < 0.01), and Kaplan–Meier survival analysis ( i ). N = 10-13 mice each.
    P2ry12 Ko Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/p2ry12+ko+mice/bio_rxiv__64898__2025__12__11__693689-141-43-49?v=Jackson+Laboratory
    Average 86 stars, based on 1 article reviews
    p2ry12 ko mice - by Bioz Stars, 2026-07
    86/100 stars

    Images

    1) Product Images from "Microglia and its P2RY12 Receptors Regulate Seizure Severity"

    Article Title: Microglia and its P2RY12 Receptors Regulate Seizure Severity

    Journal: bioRxiv

    doi: 10.64898/2025.12.11.693689

    a, Time course of modified Racine seizure scores in P2RY12-deficient mice. b , Quantification of peak seizure score in P2RY12 ⁻/⁻ mice (p < 0.05, unpaired t-test). c, Kaplan–Meier survival analysis of survival probability in P2RY12 ⁻/⁻ mice (p < 0.05, log-rank test). N = 11-18 mice each. d , Representative confocal images of IBA1 (green) and P2RY12 (magenta) immunostaining in cWT(P2RY12 fl/fl :CX3CR1 Cre/+ ) and conditional knockout cKO (P2RY12 fl/fl :CX3CR1 Cre/+) mice confirm selective microglial deletion of P2RY12. e , Quantification of P2RY12 mean fluorescence intensity in cWT and cKO mice (unpaired t-test). N = 3 mice each. f , Tail bleeding assay comparing platelet function across genotypes confirming microglia-specific targeting (p < 0.0001, one-way ANOVA with Tukey’s post hoc test). N = 4-8 mice each. g-i , Modified Racine seizure scores overtime of cWT and cKO ( g ), peak seizure score ( h , p < 0.01), and Kaplan–Meier survival analysis ( i ). N = 10-13 mice each.
    Figure Legend Snippet: a, Time course of modified Racine seizure scores in P2RY12-deficient mice. b , Quantification of peak seizure score in P2RY12 ⁻/⁻ mice (p < 0.05, unpaired t-test). c, Kaplan–Meier survival analysis of survival probability in P2RY12 ⁻/⁻ mice (p < 0.05, log-rank test). N = 11-18 mice each. d , Representative confocal images of IBA1 (green) and P2RY12 (magenta) immunostaining in cWT(P2RY12 fl/fl :CX3CR1 Cre/+ ) and conditional knockout cKO (P2RY12 fl/fl :CX3CR1 Cre/+) mice confirm selective microglial deletion of P2RY12. e , Quantification of P2RY12 mean fluorescence intensity in cWT and cKO mice (unpaired t-test). N = 3 mice each. f , Tail bleeding assay comparing platelet function across genotypes confirming microglia-specific targeting (p < 0.0001, one-way ANOVA with Tukey’s post hoc test). N = 4-8 mice each. g-i , Modified Racine seizure scores overtime of cWT and cKO ( g ), peak seizure score ( h , p < 0.01), and Kaplan–Meier survival analysis ( i ). N = 10-13 mice each.

    Techniques Used: Modification, Immunostaining, Knock-Out, Fluorescence

    a-d , Representative in vivo two photon images of microglia from P2RY12 WT, HET and KO littermates (a) used to quantify process protraction (b), retraction (c) and velocity (d). N = 3 mice each. Data shown as mean ± SEM. Statistics assessed by an ANOVA.
    Figure Legend Snippet: a-d , Representative in vivo two photon images of microglia from P2RY12 WT, HET and KO littermates (a) used to quantify process protraction (b), retraction (c) and velocity (d). N = 3 mice each. Data shown as mean ± SEM. Statistics assessed by an ANOVA.

    Techniques Used: In Vivo

    a–d , Representative confocal images ( a, c ) of IBA1 + microglia and quantification of the ramification index ( b, d ) from hippocampal CA1 ( a-b ) and the somatosensory cortex ( c-d ) regions in wildtype (WT) and P2RY12 ⁻/⁻ (KO) littermate mice under baseline (0 min) and post-seizure (90 min) conditions following kainic acid administration. Data shown as mean ± SEM. N = 4-6 mice each. Statistics done by two-way ANOVA with Tukey’s post hoc test.
    Figure Legend Snippet: a–d , Representative confocal images ( a, c ) of IBA1 + microglia and quantification of the ramification index ( b, d ) from hippocampal CA1 ( a-b ) and the somatosensory cortex ( c-d ) regions in wildtype (WT) and P2RY12 ⁻/⁻ (KO) littermate mice under baseline (0 min) and post-seizure (90 min) conditions following kainic acid administration. Data shown as mean ± SEM. N = 4-6 mice each. Statistics done by two-way ANOVA with Tukey’s post hoc test.

    Techniques Used:

    a–b , Representative confocal images of cFos immunoreactivity from the hippocampal CA1 ( a ) and somatosensory cortex ( b ) regions in wildtype (WT) and P2RY12 ⁻/⁻ (KO) mice under baseline (0 min) and post-seizure (90 min) conditions following kainic acid administration. c , Quantification of mean cFos fluorescent intensity in the CA1 (left) and cortex (right) across genotypes and time points. N = 4 mice each. Data shown as mean ± SEM. Statistics by two-way ANOVA with Tukey’s post hoc test.
    Figure Legend Snippet: a–b , Representative confocal images of cFos immunoreactivity from the hippocampal CA1 ( a ) and somatosensory cortex ( b ) regions in wildtype (WT) and P2RY12 ⁻/⁻ (KO) mice under baseline (0 min) and post-seizure (90 min) conditions following kainic acid administration. c , Quantification of mean cFos fluorescent intensity in the CA1 (left) and cortex (right) across genotypes and time points. N = 4 mice each. Data shown as mean ± SEM. Statistics by two-way ANOVA with Tukey’s post hoc test.

    Techniques Used:

    a–b, Representative confocal images of VGAT immunoreactivity from the hippocampal CA1 ( a ) and somatosensory cortex ( b ) regions in wildtype (WT) and P2RY12 ⁻/⁻ (KO) mice under baseline (0 min) and post-seizure (90 min) conditions following kainic acid administration. c , Quantification of VGAT-labeled area per μm of tissue section in the CA1 (left) and cortex (right) across genotypes and time points. N = 4 mice each. Data shown as mean ± SEM. Statistics by two-way ANOVA with Tukey’s post hoc test.
    Figure Legend Snippet: a–b, Representative confocal images of VGAT immunoreactivity from the hippocampal CA1 ( a ) and somatosensory cortex ( b ) regions in wildtype (WT) and P2RY12 ⁻/⁻ (KO) mice under baseline (0 min) and post-seizure (90 min) conditions following kainic acid administration. c , Quantification of VGAT-labeled area per μm of tissue section in the CA1 (left) and cortex (right) across genotypes and time points. N = 4 mice each. Data shown as mean ± SEM. Statistics by two-way ANOVA with Tukey’s post hoc test.

    Techniques Used: Labeling



    Similar Products

    p2ry12 ko mice  (Jackson Laboratory)
    86
    Jackson Laboratory p2ry12 ko mice
    a, Time course of modified Racine seizure scores in <t>P2RY12-deficient</t> mice. b , Quantification of peak seizure score in P2RY12 ⁻/⁻ mice (p < 0.05, unpaired t-test). c, Kaplan–Meier survival analysis of survival probability in P2RY12 ⁻/⁻ mice (p < 0.05, log-rank test). N = 11-18 mice each. d , Representative confocal images of IBA1 (green) and P2RY12 (magenta) immunostaining in cWT(P2RY12 fl/fl :CX3CR1 Cre/+ ) and conditional knockout cKO (P2RY12 fl/fl :CX3CR1 Cre/+) mice confirm selective microglial deletion of P2RY12. e , Quantification of P2RY12 mean fluorescence intensity in cWT and cKO mice (unpaired t-test). N = 3 mice each. f , Tail bleeding assay comparing platelet function across genotypes confirming microglia-specific targeting (p < 0.0001, one-way ANOVA with Tukey’s post hoc test). N = 4-8 mice each. g-i , Modified Racine seizure scores overtime of cWT and cKO ( g ), peak seizure score ( h , p < 0.01), and Kaplan–Meier survival analysis ( i ). N = 10-13 mice each.
    P2ry12 Ko Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/p2ry12+ko+mice/bio_rxiv__64898__2025__12__11__693689-141-43-49?v=Jackson+Laboratory
    Average 86 stars, based on 1 article reviews
    p2ry12 ko mice - by Bioz Stars, 2026-07
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    a, Time course of modified Racine seizure scores in P2RY12-deficient mice. b , Quantification of peak seizure score in P2RY12 ⁻/⁻ mice (p < 0.05, unpaired t-test). c, Kaplan–Meier survival analysis of survival probability in P2RY12 ⁻/⁻ mice (p < 0.05, log-rank test). N = 11-18 mice each. d , Representative confocal images of IBA1 (green) and P2RY12 (magenta) immunostaining in cWT(P2RY12 fl/fl :CX3CR1 Cre/+ ) and conditional knockout cKO (P2RY12 fl/fl :CX3CR1 Cre/+) mice confirm selective microglial deletion of P2RY12. e , Quantification of P2RY12 mean fluorescence intensity in cWT and cKO mice (unpaired t-test). N = 3 mice each. f , Tail bleeding assay comparing platelet function across genotypes confirming microglia-specific targeting (p < 0.0001, one-way ANOVA with Tukey’s post hoc test). N = 4-8 mice each. g-i , Modified Racine seizure scores overtime of cWT and cKO ( g ), peak seizure score ( h , p < 0.01), and Kaplan–Meier survival analysis ( i ). N = 10-13 mice each.

    Journal: bioRxiv

    Article Title: Microglia and its P2RY12 Receptors Regulate Seizure Severity

    doi: 10.64898/2025.12.11.693689

    Figure Lengend Snippet: a, Time course of modified Racine seizure scores in P2RY12-deficient mice. b , Quantification of peak seizure score in P2RY12 ⁻/⁻ mice (p < 0.05, unpaired t-test). c, Kaplan–Meier survival analysis of survival probability in P2RY12 ⁻/⁻ mice (p < 0.05, log-rank test). N = 11-18 mice each. d , Representative confocal images of IBA1 (green) and P2RY12 (magenta) immunostaining in cWT(P2RY12 fl/fl :CX3CR1 Cre/+ ) and conditional knockout cKO (P2RY12 fl/fl :CX3CR1 Cre/+) mice confirm selective microglial deletion of P2RY12. e , Quantification of P2RY12 mean fluorescence intensity in cWT and cKO mice (unpaired t-test). N = 3 mice each. f , Tail bleeding assay comparing platelet function across genotypes confirming microglia-specific targeting (p < 0.0001, one-way ANOVA with Tukey’s post hoc test). N = 4-8 mice each. g-i , Modified Racine seizure scores overtime of cWT and cKO ( g ), peak seizure score ( h , p < 0.01), and Kaplan–Meier survival analysis ( i ). N = 10-13 mice each.

    Article Snippet: This study used both male and female mice on a C57BL/6J background between 2-4 months of age, and consisted of the following genotypes: C57Bl/6J mice as wildtype mice; CX3CR1 GFP/+ expressing GFP under control of the fractalkine receptor (CX3CR1) promoter (Jackson Lab, #005582); P2RY12 KO mice; CX3CR1 Cre mice (Jackson Lab, #025524); P2RY12 fl/fl mice as a generous gift from Dr. Long-Jun Wu at the University of Texas Health in Houston; Csf1r ΔFIRE/ΔFIRE as a generous gift from Dr. Sandro da Mesquita, Mayo Clinic.

    Techniques: Modification, Immunostaining, Knock-Out, Fluorescence

    a-d , Representative in vivo two photon images of microglia from P2RY12 WT, HET and KO littermates (a) used to quantify process protraction (b), retraction (c) and velocity (d). N = 3 mice each. Data shown as mean ± SEM. Statistics assessed by an ANOVA.

    Journal: bioRxiv

    Article Title: Microglia and its P2RY12 Receptors Regulate Seizure Severity

    doi: 10.64898/2025.12.11.693689

    Figure Lengend Snippet: a-d , Representative in vivo two photon images of microglia from P2RY12 WT, HET and KO littermates (a) used to quantify process protraction (b), retraction (c) and velocity (d). N = 3 mice each. Data shown as mean ± SEM. Statistics assessed by an ANOVA.

    Article Snippet: This study used both male and female mice on a C57BL/6J background between 2-4 months of age, and consisted of the following genotypes: C57Bl/6J mice as wildtype mice; CX3CR1 GFP/+ expressing GFP under control of the fractalkine receptor (CX3CR1) promoter (Jackson Lab, #005582); P2RY12 KO mice; CX3CR1 Cre mice (Jackson Lab, #025524); P2RY12 fl/fl mice as a generous gift from Dr. Long-Jun Wu at the University of Texas Health in Houston; Csf1r ΔFIRE/ΔFIRE as a generous gift from Dr. Sandro da Mesquita, Mayo Clinic.

    Techniques: In Vivo

    a–d , Representative confocal images ( a, c ) of IBA1 + microglia and quantification of the ramification index ( b, d ) from hippocampal CA1 ( a-b ) and the somatosensory cortex ( c-d ) regions in wildtype (WT) and P2RY12 ⁻/⁻ (KO) littermate mice under baseline (0 min) and post-seizure (90 min) conditions following kainic acid administration. Data shown as mean ± SEM. N = 4-6 mice each. Statistics done by two-way ANOVA with Tukey’s post hoc test.

    Journal: bioRxiv

    Article Title: Microglia and its P2RY12 Receptors Regulate Seizure Severity

    doi: 10.64898/2025.12.11.693689

    Figure Lengend Snippet: a–d , Representative confocal images ( a, c ) of IBA1 + microglia and quantification of the ramification index ( b, d ) from hippocampal CA1 ( a-b ) and the somatosensory cortex ( c-d ) regions in wildtype (WT) and P2RY12 ⁻/⁻ (KO) littermate mice under baseline (0 min) and post-seizure (90 min) conditions following kainic acid administration. Data shown as mean ± SEM. N = 4-6 mice each. Statistics done by two-way ANOVA with Tukey’s post hoc test.

    Article Snippet: This study used both male and female mice on a C57BL/6J background between 2-4 months of age, and consisted of the following genotypes: C57Bl/6J mice as wildtype mice; CX3CR1 GFP/+ expressing GFP under control of the fractalkine receptor (CX3CR1) promoter (Jackson Lab, #005582); P2RY12 KO mice; CX3CR1 Cre mice (Jackson Lab, #025524); P2RY12 fl/fl mice as a generous gift from Dr. Long-Jun Wu at the University of Texas Health in Houston; Csf1r ΔFIRE/ΔFIRE as a generous gift from Dr. Sandro da Mesquita, Mayo Clinic.

    Techniques:

    a–b , Representative confocal images of cFos immunoreactivity from the hippocampal CA1 ( a ) and somatosensory cortex ( b ) regions in wildtype (WT) and P2RY12 ⁻/⁻ (KO) mice under baseline (0 min) and post-seizure (90 min) conditions following kainic acid administration. c , Quantification of mean cFos fluorescent intensity in the CA1 (left) and cortex (right) across genotypes and time points. N = 4 mice each. Data shown as mean ± SEM. Statistics by two-way ANOVA with Tukey’s post hoc test.

    Journal: bioRxiv

    Article Title: Microglia and its P2RY12 Receptors Regulate Seizure Severity

    doi: 10.64898/2025.12.11.693689

    Figure Lengend Snippet: a–b , Representative confocal images of cFos immunoreactivity from the hippocampal CA1 ( a ) and somatosensory cortex ( b ) regions in wildtype (WT) and P2RY12 ⁻/⁻ (KO) mice under baseline (0 min) and post-seizure (90 min) conditions following kainic acid administration. c , Quantification of mean cFos fluorescent intensity in the CA1 (left) and cortex (right) across genotypes and time points. N = 4 mice each. Data shown as mean ± SEM. Statistics by two-way ANOVA with Tukey’s post hoc test.

    Article Snippet: This study used both male and female mice on a C57BL/6J background between 2-4 months of age, and consisted of the following genotypes: C57Bl/6J mice as wildtype mice; CX3CR1 GFP/+ expressing GFP under control of the fractalkine receptor (CX3CR1) promoter (Jackson Lab, #005582); P2RY12 KO mice; CX3CR1 Cre mice (Jackson Lab, #025524); P2RY12 fl/fl mice as a generous gift from Dr. Long-Jun Wu at the University of Texas Health in Houston; Csf1r ΔFIRE/ΔFIRE as a generous gift from Dr. Sandro da Mesquita, Mayo Clinic.

    Techniques:

    a–b, Representative confocal images of VGAT immunoreactivity from the hippocampal CA1 ( a ) and somatosensory cortex ( b ) regions in wildtype (WT) and P2RY12 ⁻/⁻ (KO) mice under baseline (0 min) and post-seizure (90 min) conditions following kainic acid administration. c , Quantification of VGAT-labeled area per μm of tissue section in the CA1 (left) and cortex (right) across genotypes and time points. N = 4 mice each. Data shown as mean ± SEM. Statistics by two-way ANOVA with Tukey’s post hoc test.

    Journal: bioRxiv

    Article Title: Microglia and its P2RY12 Receptors Regulate Seizure Severity

    doi: 10.64898/2025.12.11.693689

    Figure Lengend Snippet: a–b, Representative confocal images of VGAT immunoreactivity from the hippocampal CA1 ( a ) and somatosensory cortex ( b ) regions in wildtype (WT) and P2RY12 ⁻/⁻ (KO) mice under baseline (0 min) and post-seizure (90 min) conditions following kainic acid administration. c , Quantification of VGAT-labeled area per μm of tissue section in the CA1 (left) and cortex (right) across genotypes and time points. N = 4 mice each. Data shown as mean ± SEM. Statistics by two-way ANOVA with Tukey’s post hoc test.

    Article Snippet: This study used both male and female mice on a C57BL/6J background between 2-4 months of age, and consisted of the following genotypes: C57Bl/6J mice as wildtype mice; CX3CR1 GFP/+ expressing GFP under control of the fractalkine receptor (CX3CR1) promoter (Jackson Lab, #005582); P2RY12 KO mice; CX3CR1 Cre mice (Jackson Lab, #025524); P2RY12 fl/fl mice as a generous gift from Dr. Long-Jun Wu at the University of Texas Health in Houston; Csf1r ΔFIRE/ΔFIRE as a generous gift from Dr. Sandro da Mesquita, Mayo Clinic.

    Techniques: Labeling